Research > Research 게시판목록 | 이화여자대학교 약학대학(영문)

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Prof. Eun Joo Song’ research has been published in Nature Communications

Prof. Eun-Joo Song's research team discovered for the first time a new degradation mechanism of tau protein, which is known as an important cause of Alzheimer's disease,. This work was conducted through collaboration with the Korea Research Institute of Bioscience & Biotechnology(co-corresponding author Kweon Yu) and the Korea Institute of Science and Technology (co-corresponding author Hoon Ryu), and published in Nature Communications (IF 12.121). The paper was published on the 2nd of June in 2021. Alzheimer's disease is one of the most lethal degenerative brain diseases in modern people, and aggregation of tau protein together with amyloid beta is considered as one of the causes. In this study, in addition to CHIP, which ubiquitinates tau protein, UBE4B, an enzyme that significantly increases ubiquitination as an E3/E4 ligase, was newly discovered. When CHIP and UBE4B are overexpressed, tau oligomers are degraded not only in cells but also in animal models. And we found that the tau protein is degraded mainly via autophagy pathway. This study suggested the possibility of developing new therapeutic agents using UBE4B as well as preventing Alzheimer's disease caused by tau aggregation and tauopathy, and it is expected to provide a very important clue in the future development of Alzheimer's drugs. This research was supported by the National Research Foundation of Korea (Basic Research Lab and Mid-level Researcher Support Project).
- 작성자약학대학
- 작성일2021.06.11
- 조회수706
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Prof. Eun Sook Hwang’s LAB Nature Communications, 2019

Prof. Hwang's lab published research article entitled "TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression" in Nature Communications, which was conducted by Hyo Kyeong Kim and Hana Jeong under collaboration with Prof. Hong's lab in Korea University. This work identifies TAZ as a potential beneficial regulator for controlling insulin resistance through regulation of Irs1 in muscle. As TAZ deficiency in muscle tissues impairs insulin sensitivity in animal model, TAZ is believed to be essential for modulating glucose homeostasis in muscle tissues and important for preventing from diabetes development. This work was supported by Fibrosis Control Center funded by the National Research Foundation of Korea. 발표논문제목: TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression
- 작성자약학대학
- 작성일2020.09.29
- 조회수725
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Professor In Kyoon Lyoo’s research team reported that alterations in functional brain networks

Professor In Kyoon Lyoo’s research team reported that alterations in functional brain networks induced by inflammation and stress mediate the development of posttraumatic stress disorder symptoms. A research team lead by Professor In Kyoon Lyoo has reported the relationship between low-grade inflammation and the risk of posttraumatic stress disorder (PTSD). They showed that reduced functional couplings among the higher-order cognitive networks might mediate the development of PTSD in individuals with low-grade inflammation and repetitive stress. The current study was published in the Nature Communications and was selected as Editors' Highlights (co-1st authors: Professors Jungyoon Kim and Sujung Yoon; corresponding author: Professor In Kyoon Lyoo). In this paper, Professor Lyoo and colleagues reported that low-grade inflammation might render individuals more vulnerable to PTSD when exposed to repetitive stress. Low-grade inflammation, defined as increased pro-inflammatory substances in the peripheral blood, was linked to the reduced inter-network functional connectivity among brain networks. The reduced functional connectivity was subsequently related to more severe PTSD symptoms. The current study results provide a neurobiological basis that peripheral inflammatory substances may be used as predictive markers for the individuals' vulnerability to PTSD at pre-clinical stages. Title of the article: "A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms"
- 작성자약학대학
- 작성일2020.09.28
- 조회수720
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Professor Jeong Yeon Rhie’s research has been published in British Journal of Sports Medicine

Development of Pharmaceutical Care in Sports Medicine A research team led by Professor Jeong Yeon Rhie at the College of Pharmacy published the article entitled ‘Pharmacy services at the PyeongChang 2018 Olympic and Paralympic Winter Games’ in the British Journal of Sports Medicine (IF 11.645, the 1st of the JCR rank). The research team showed that the pharmaceutical care program during the Games was beneficial in managing athletes’ physical and mental health at the competition. Moreover, the pharmacovigilance activity was indicated to help preventing the spread of disease among athletes. Professor Rhie suggested that pharmacy professionals should understand athletes’ demands on the proper use of medications and anti-doping policies, including the therapeutic use exemption and needle policy, to further achieve positive outcomes from the pharmaceutical care program in Sports.
- 작성자약학대학
- 작성일2020.09.28
- 조회수466
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Professor Youngjoo Kwon’s research team has published an article in “Pharmacology & Therapeutics” journal

Professor Youngjoo Kwon and her Ph.D candidates (all currently post-doc researchers), Soo-Yeon Hwang and Seojeong Park published a paper in the world-renowned journal, “Pharmacology & Therapeutics” (IF: 10.557, JCR ranking top 2.6%) on July, 2019. In this paper, they have extensively reviewed pathological mechanisms and diverse therapeutic targets for triple negative breast cancer (TNBC). The article comprehensively deals with the complicated tumorigenic processes and discusses critical findings and therapeutic trends in TNBC with a focus on promising therapeutic approaches. This article also summarizes the clinical trials currently underway, and potent experimental compounds under preclinical and evaluation. Professor Kwon stated that the major significance of this paper is that it may provide an academic foundation for future efforts to establish competitive drug development strategies for incurable diseases like TNBC. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2018R1A5A2025286) and (2018R1A2B2006115). *Original article: “Recent therapeutic trends and promising targets in triple negative breast cancer”
- 작성자약학대학
- 작성일2020.09.28
- 조회수381